Alabama Newscenter — UAB-Developed Viral Immunotherapy for Pediatric Brain Tumors Shows Promise

By Bob Shepard

A modified herpes virus, alone and in combination with radiation, has been shown to be well-tolerated and effective in children with high-grade brain tumors – or gliomas – researchers have found at the University of Alabama at Birmingham and Children’s of Alabama.

The findings were presented at the virtual American Association for Cancer Research Annual Meeting 2021 April 10-15 and published online in the New England Journal of Medicine.

Brain tumors are the most common solid tumor in children, and aggressive types like glioblastoma have an extremely low survival rate, as low as 10% five years after diagnosis. Even tumors successfully treated by surgery, radiation and chemotherapy have a high recurrence rate.

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