Novel Diabetes Drug Candidate Discovered by UAB, Southern Research Shows Promise in Tests of Humans and Mice

| August 4, 2020 @ 6:00 pm

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By Jeff Hansen

The University of Alabama at Birmingham and Southern Research have discovered a compound that offers a major advance in the oral treatment of diabetes.

Tested on isolated human and mouse pancreatic subjects, mouse and rat cell cultures and animal models of Type 1 and Type 2 diabetes, the experimental drug significantly improved four detrimental characteristics of diabetes: high blood sugar; elevation in the hormone glucagon that counteracts the effects of insulin, promotes glucose production and increases blood glucose; excessive production of glucose by the liver; and fatty liver.

The drug candidate SRI-37330 is a nontoxic small molecule that effectively rescued mice from streptozotocin- and obesity-induced diabetes and improved glucose homeostasis.

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