HudsonAlpha Scientists Help Identify Important Parts of the Human Genome

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By HudsonAlpha Institute for Biotechnology

For nearly two decades, researchers at HudsonAlpha Institute for Biotechnology, along with collaborators at Caltech, Penn State and UC Irvine, have been trying to understand how the human genome functions. As members of the Encyclopedia of DNA Elements (ENCODE) Project, a worldwide effort, they have been performing experiments and data analysis to elucidate the importance of the 98% of the genome that does not code for proteins.

During phase three of ENCODE, consortium researchers drew closer to their goal of developing a comprehensive map of the functional elements of human and mouse genomes by adding to the database millions of candidate DNA switches that regulate when and where genes are turned on.

Results, including a manuscript from the Myers and Mendenhall labs at HudsonAlpha, were published July 30 as a nine-manuscript compendium in the scientific journal Nature, accompanied by 21 additional in-depth studies published in other major journals.

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