Alabama NewsCenter — UAB announces first clinical-grade transplant of gene-edited pig kidneys into brain-dead human

| January 22, 2022 @ 6:00 pm

By Tyler Greer

The UAB Marnix E. Heersink School of Medicine has announced the first peer-reviewed research outlining the successful transplant of genetically modified, clinical-grade pig kidneys into a brain-dead human, replacing the recipient’s kidneys. These positive results demonstrate how xenotransplantation could address the worldwide organ shortage crisis.

In a study published in the American Journal of Transplantation, UAB researchers tested the first human preclinical model for transplanting genetically modified pig kidneys into humans. The study recipient had two genetically modified pig kidneys transplanted in his abdomen after his native kidneys were removed. The organs were procured from a genetically modified pig at a pathogen-free facility.

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